发明名称 |
NUCLEAR MAGNETIC RESONANCE DIAGNOSTIC AGENT, AND METHOD FOR DETECTING OR DIAGNOSING STATE OF CELL, TISSUE OR ORGAN IN SUBJECT USING SAME |
摘要 |
[Problem] To provide a nuclear magnetic resonance diagnostic agent that has a lower toxicity to organisms and reduced side effects and yet has a site specificity toward a specific cell, tissue, organ, etc. [Solution] When ALA or an ALA derivative is administered in vivo, a metabolite thereof is accumulated in a specific cell, tissue, organ, etc. Focusing on this phenomenon, a nuclear magnetic resonance analysis was performed on a site wherein the metabolite of ALA that had been administered in vivo would be possibly accumulated. As a result, it was surprisingly found that ALA and an ALA derivative are useful as a diagnostic agent whereby the aforesaid problem can be solved. |
申请公布号 |
WO2014092051(A1) |
申请公布日期 |
2014.06.19 |
申请号 |
WO2013JP82974 |
申请日期 |
2013.12.09 |
申请人 |
NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY;UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, JAPAN;SBI PHARMACEUTICALS CO., LTD. |
发明人 |
YONEDA, TETSUYA;NISHIZAWA, SHIGERU;YAMAMOTO, JUNKOH;TANAKA, TOHRU;ITOH, HIDENORI |
分类号 |
A61K49/00;A61B5/055;G01R33/28 |
主分类号 |
A61K49/00 |
代理机构 |
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