| 摘要 |
<p>A nanoscale platinum drug particle and a preparation method thereof. In the nanoscale platinum drug particle, silicon dioxide aerogel is used as a carrier of the platinum drug. The silicon dioxide aerogel has porosity of 95% to 99%, a pore diameter of 10 to 50nm, a specific surface area of 200 to 1000 m2/g, and a density of 3 to 300 kg/m3; a colloidal particle diameter of a formed network is 1 to 50nm. The platinum drug is absorbed in pores of the silicon dioxide aerogel to form the nanoscale platinum drug particle with a diameter less than 100nm. The preparation method comprises: dissolving the platinum drug in a 1.5%(W/V) Nacl solution, adding the silicon dioxide aerogel, drying after complete adsorption, adding purified water and delivering the mixture to an emulsifying machine for emulsification, then homogenizing mixture by using a high-pressure homogenizer, and drying the obtained homogenate to obtain the nanoscale platinum drug particle.</p> |
