METHOD OF MAKING COATED MICROSTRUCTURES

摘要

Coated microneedle devices and methods of making such devices are provided. In one aspect, a method for coating includes providing a microstructure having at least one surface in need of coating; and applying a coating liquid, which includes at least one drug, to the at least one surface of the microstructure, wherein the surface energy of the coating liquid is less than the surface energy of the surface of the microstructure. The coating liquid may include a viscosity enhancer and surfactant. Microneedles having heterogeneous coatings, pockets, or both are also provided.

主权项

1. A method for coating at least one microneedle comprising:
providing a coating liquid disposed in one or more reservoirs, the coating liquid comprising at least one drug; providing a physical mask having one or more apertures, each aperture having cross-section dimensions larger than the at least one microneedle to be coated; aligning the at least one microneedle with at least one of the one or more apertures; inserting the at least one microneedle through the aligned aperture and into the coating liquid, thereby coating at least a portion of the microneedle; and removing the coated microneedle from the coating liquid and from the aperture.