| 发明名称 |
GLYPICAN-3-SPECIFIC ANTIBODY AND USES THEREOF |
| 摘要 |
The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of GPC3. The invention provides novel antibodies that specifically bind to glypican-3 (GPC3). The invention also relates to a fully human chimeric antigen receptor (CAR) wherein the CAR is able to target GPC3. |
| 申请公布号 |
US2014170114(A1) |
申请公布日期 |
2014.06.19 |
| 申请号 |
US201414181870 |
申请日期 |
2014.02.17 |
| 申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
Kaplan David |
| 分类号 |
C07K16/30 |
主分类号 |
C07K16/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated polynucleotide encoding a human anti-GPC3 antibody or a fragment thereof comprising a heavy chain and light chain, wherein the amino acid sequence of the heavy chain is selected from the group consisting of SEQ ID NOs: 12-16 and the amino acid sequence of the light chain is selected from the group consisting of SEQ ID NOs: 17-21.
|
| 地址 |
Philadelphia PA US |
