发明名称 |
METHODS FOR IDENTIFYING AN INCREASED RISK OF ANTHRACYCLINE-RELATED CARDIOTOXICITY |
摘要 |
Methods of identifying a subject having an increased risk of developing anthracycline-related cardiotoxicity are provided. Such methods may include isolating a DNA sample from a biological specimen from the subject; genotyping the DNA sample to determine a copy number of a variant allele that increases the risk of developing chemotherapy-induced cardiotoxicity; and identifying the subject as having an increased risk of developing anthracycline-related cardiotoxicity when the copy number is at least one. In some embodiments, the methods may include optimally administering a therapeutically effective dose of a chemotherapy agent or an alternative non-cardiotoxic chemotherapeutic agent to the subject. |
申请公布号 |
US2014171382(A1) |
申请公布日期 |
2014.06.19 |
申请号 |
US201314101006 |
申请日期 |
2013.12.09 |
申请人 |
CITY OF HOPE |
发明人 |
Bhatia Smita |
分类号 |
C12Q1/68;A61K45/06;A61K31/704 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A method of identifying a subject having an increased risk of developing anthracycline-related cardiotoxicity comprising:
isolating a DNA sample from a biological specimen from the subject; genotyping the DNA sample to determine a copy number of a variant allele that increases the risk of developing chemotherapy-induced cardiotoxicity; and identifying the subject as having an increased risk of developing anthracycline-related cardiotoxicity when the copy number is at least one.
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地址 |
Duarte CA US |