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1. A compound of Formula I: stereoisomers, tautomers, solvates, prodrugs and pharmaceutically acceptable salts thereof, wherein: A is CR3 or N; X is CR15 or N; R1 is independently hydrogen, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, —CF3, —OR6, —SR6, —OCF3, —CN, —NO2, —C(O)R6, —C(O)OR6, —C(O)NR6R7, —S(O)1-2R6, —S(O)1-2NR6R7, —NR6S(O)1-2R7, —NR6SO2NR6R7, —NR6C(O)R7, —NR6C(O)OR7, —NR6C(O)NR6R7, —OC(O)NR6R7 or —NR6R7, wherein both R1 cannot be hydrogen at the same time, and wherein said alkyl, alkenyl, alkynyl and cycloalkyl are optionally substituted by halogen, oxo, —CN, OR6, —NR6R7, C3-C6 cycloalkyl, 3-6 membered heterocyclyl or phenyl and said cycloalkyl, heterocyclyl and phenyl are independently optionally substituted by R10; R2 and R3 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, —(C0-C3 alkylene)CN, —(C0-C3 alkylene)OR8, —(C0-C3 alkylene)SR8, —(C0-C3 alkylene)NR8R9, —(C0-C3 alkylene)CF3, —O(C0-C3 alkylene)CF3, —(C0-C3 alkylene)NO2, —(C0-C3 alkylene)C(O)R8, —(C0-C3 alkylene)C(O)OR8, —(C0-C3 alkylene)C(O)NR8R9, —(C0-C3 alkylene)NR8C(O)R9, —(C0-C3 alkylene)S(O)1-2R8, —(C0-C3 alkylene)NR8S(O)1-2R9, —(C0-C3 alkylene)S(O)1-2NR8R9, —(C0-C3 alkylene)(C3-C6 cycloalkyl), —(C0-C3 alkylene)(3-10-membered heterocyclyl), —(C0-C3 alkylene)(5-10-membered heteroaryl) or —(C0-C3 alkylene)phenyl, wherein R2 and R3 are each independently optionally substituted by R10; R4 is hydrogen, —NR6—, —NR6R7, —NR6C(O)—, —NR6C(O)O—, —NR6C(O)NR7—, NR6S(O)1-2— or —NR6S(O)1-2NR7—; R5 is absent, hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, C6-C10 aryl, 3-10-membered heterocyclyl or 5-10-membered heteroaryl, wherein R5 is optionally substituted by R10; R6 and R7 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, wherein said alkyl, alkenyl, alkynyl and cycloalkyl are independently optionally substituted by halogen, C1-C6 alkyl, oxo, —CN, —OR11 or —NR11R12; or R6 and R7 are independently taken together with the atom to which they are attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo, —OR11, —NR11R12 or C1-C6 alkyl optionally substituted by halogen; R8 and R9 are each independently hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, phenyl, 3-6-membered heterocyclyl or 5-6-membered heteroaryl, wherein said alkyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl are independently optionally substituted by R10; or R8 and R9 are independently taken together with the atom to which they are attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo, —NR11R12 or C1-C6 alkyl; R10 is independently hydrogen, oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, —(C0-C3 alkylene)CN, —(C0-C3 alkylene)OR11, —(C0-C3 alkylene)SR11, —(C0-C3 alkylene)NR11R12, —(C0-C3 alkylene)CF3, —(C0-C3 alkylene)NO2, —C═NH(OR11), —(C0-C3 alkylene)C(O)R11, —(C0-C3 alkylene)C(O)OR11, —(C0-C3 alkylene)C(O)NR11R12, —(C0-C3 alkylene)NR11C(O)R12, —(C0-C3 alkylene)S(O)1-2R11, —(C0-C3 alkylene)NR11S(O)1-2R12, —(C0-C3 alkylene)S(O)1-2NR11R12, —(C0-C3 alkylene)(C3-C6 cycloalkyl), —(C0-C3 alkylene)(3-10-membered heterocyclyl), —(C0-C3 alkylene)C(O)(3-10-membered heterocyclyl), —(C0-C3 alkylene)(5-10-membered heteroaryl) or —(C0-C3 alkylene)phenyl, wherein R10 is independently optionally substituted by halogen, oxo, —CF3, —(C0-C3 alkylene)OR13, —(C0-C3 alkylene)NR13R14, —(C0-C3 alkylene)C(O)R13, —(C0-C3 alkylene)S(O)1-2R13 or C1-C6 alkyl optionally substituted by oxo, —CN or halogen; R11 and R12 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, phenyl, 5-6 membered heteroaryl or 3-6 membered heterocyclyl, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heteroaryl and heterocyclyl are independently optionally substituted by halogen, oxo, —CN, —OR16, —NR16R17 or C1-C6 alkyl optionally substituted by halogen, —CN or oxo; or R11 and R12 are taken together with the atom to which they attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo, —OR16, —NR16R17 or C1-C6 alkyl optionally substituted by halogen, oxo or OH; R13 and R14 are each independently hydrogen or C1-C6 alkyl optionally substituted by halogen or oxo; or R13 and R14 are taken together with the atom to which they attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo or C1-C6 alkyl optionally substituted by halogen or oxo; R15 is hydrogen, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, —(C0-C3 alkylene)CN, —(C0-C3 alkylene)OR18, —(C0-C3 alkylene)SR18, —(C0-C3 alkylene)NR18R19, —(C0-C3 alkylene)CF3, —O(C0-C3 alkylene)CF3, —(C0-C3 alkylene)NO2, —(C0-C3 alkylene)C(O)R18, —(C0-C3 alkylene)C(O)OR18, —(C0-C3 alkylene)C(O)NR18R19, —(C0-C3 alkylene)NR18C(O)R19, —(C0-C3 alkylene)S(O)1-2R18, —(C0-C3 alkylene)NR18S(O)1-2R19, —(C0-C3 alkylene)S(O)1-2NR18R19, —(C0-C3 alkylene)(C3-C6 cycloalkyl), —(C0-C3 alkylene)(3-6-membered heterocyclyl), —(C0-C3 alkylene)(5-6-membered heteroaryl) or —(C0-C3 alkylene)phenyl; R16 and R17 are each independently hydrogen or C1-C6 alkyl optionally substituted by halogen or oxo; or R16 and R17 are taken together with the atom to which they attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo or C1-C6 alkyl optionally substituted by oxo or halogen; and R18 and R19 are each independently hydrogen or C1-C6 alkyl optionally substituted by halogen or oxo; other than 2-(2-chlorophenyl)thiazolo[5,4-c]pyridine, 2-(thiazolo[5,4-c]pyridin-2-yl)aniline, 2-phenoxy-N-(2-thiazolo[5,4-c]pyridin-2-yl-phenyl)-propanamide, N-(2-thiazolo[5,4-c]pyridin-2-ylphenyl)-benzenepropanamide, 2-(2-methylphenyl)-thiazolo[5,4-c]pyridine, 2-[2-methoxy-4-(methylthio)phenyl]-thiazolo[5,4-c]pyridine and 2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridine.
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