发明名称 |
MODULATION OF MYOFIBER REPAIR BY ANTI-MYOSTATIN IN STRATEGIES WITH STEM CELLS |
摘要 |
<p>Treating or inhibiting an ischemic condition affecting the skeletal muscle comprising administering an agent having a property to inhibit an activity or a protein expression of myostatin or growth differentiation factor 8 (GDF-8) according to a regimen to treat or inhibit the ischemic condition. Treating or inhibiting an ischemic condition affecting the skeletal muscle including administering an effective amount of a thiazolidenedione or other PPAR gamma agonist at a dosage that do not exert glycemic control or induce overweight. A kit for use in treating or inhibiting an ischemic condition affecting the skeletal muscle comprising a quantity of an agent having a property to inhibit an activity or a protein expression of myostatin or growth differentiation factor 8 (GDF-8) and/or a quantity of a thiazolidenedione or other PPAR gamma agonist and instructions for administration of a dosage of that quantity according to a long term continuous regimen.</p> |
申请公布号 |
WO2014093531(A1) |
申请公布日期 |
2014.06.19 |
申请号 |
WO2013US74467 |
申请日期 |
2013.12.11 |
申请人 |
LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER |
发明人 |
GONZALEZ-CADAVID, NESTOR F.;WHITE, RODNEY A. |
分类号 |
A61K31/425;A01N43/78;A61K39/395;A61K48/00;C07D277/00;C07K2/00;C07K16/18;C12N5/071 |
主分类号 |
A61K31/425 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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