| 发明名称 |
Fc variants with altered binding to FcRn |
| 摘要 |
UOCKet NO.: OUZO-VVUU The present application relates toa variant Fc-region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index. |
| 申请公布号 |
AU2014202872(A1) |
申请公布日期 |
2014.06.19 |
| 申请号 |
AU20140202872 |
申请日期 |
2014.05.27 |
| 申请人 |
XENCOR, INC |
发明人 |
CHAMBERLAIN, AARON;DAHIYAT, BASSIL;KARKI, SHER BAHADUR;DESJARLAIS, JOHN RUDOLPH;LAZAR, GREGORY ALAN |
| 分类号 |
C07K16/22;C07K16/24;C07K16/28 |
主分类号 |
C07K16/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
