Synthetic Oligosaccharides for Staphylococcus Vaccine

摘要

The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)-glucosamine species having a definite number of monosaccharide units, including a set pattern of acetylated and non-acetylated residues. The invention further provides antibodies to these synthetic oligo-β-(1→6)-glucosamines as well as compositions thereof and methods for treating and preventing infections caused by bacteria expressing poly-β-(1→6)-glucosamines, such as Staphylococcus aureus.

主权项

1. A homogenous composition consisting essentially of a synthetic oligosaccharide 1a wherein R1 and R2 are independently selected from H or C(O)CH3; n is an integer of at least 3, X is a bond or a linker, and Y is H or a carrier; wherein at least one R1 or R2 in the oligosaccharide is H and at least another one is C(O)CH3; wherein each occurrence of R1 can be the same or different.