| 摘要 |
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative. |
| 主权项 |
1. A compound of Formula Iwherein:
X is O or S; Y is O or S; R1 is —NH(C═O)—(CH2)nNC(═N)NH2, —NH(CH2)nNH2, —NH(CH2)nNC(═N)NH2, —(CH2)nNH2, —(CH2)nNC(═N)NH2, —O—(CH2)nNH2, or —O—(CH2)nNC(═N)NH2, where n is 1, 2, 3, or 4; R2 is —S(CH2)zNH2, —(CH2)zNH2, —(CH2)zNC(═N)NH2, or —O—(CH2)zNH2, or —O—(CH2)zNC(═N)NH2, where z is 1, 2, 3, or 4; R3 is —CF3, F, Cl, or Br; R4 is —N(═O)2, —NH2, —N(CH2)qNH2, or —NC(═N)NH2, where q is 1, 2, 3, or 4; R5 is —CF3, H, F, Cl, or Br; and R6 is H, —(CH2)rNH2, —O—(CH2)rNH2, or —O—(CH2)rNC(═N)NH2, where r is 1, 2, 3, or 4;or a pharmaceutically acceptable salt thereof.
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