NOVEL PHARMACEUTICAL FORMULATION OF CEFIXIME FOR ENHANCED BIOAVAILABILITY

摘要

A chewable tablet comprising Cefixime having a mean particle size between 20μ and 120μ wherein the said composition demonstrates bioequivalence to a suspension of Cefixime trihydrate. The process of preparation of the chewable tablet comprises the steps of optionally micronizing Cefixime such that the mean particle size of the Cefixime particles is between 20μ and 120μ, blending with other excipients, roll compaction, milling to form granules, blending to form a secondary blend and compression of the secondary blend to form tablets.

主权项

1. A process of preparing a chewable tablet comprising Cefixime, the process comprising: optionally, micronizing Cefixime to obtain Cefixime particles of mean particle size 20μ to 120μ; blending cefixime, mannitol, hydroxypropyl cellulose and crospovidone; subjecting the blend to slugging; milling the slugs to obtain granules; blending the granules with one or more pharmaceutically acceptable excipients to obtain a secondary blend; and compressing the secondary blend to obtain a chewable tablet.