| 发明名称 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROMYELITIS OPTICA |
| 摘要 |
The present invention is directed to antibodies binding to aquaporin 4 (AQP4) and methods of using such antibodies to treat neuromyelitis optica (NMO) either as a monotherapy or in combination with standard NMO therapies such as immunosuppressives or plasmaphersis. |
| 申请公布号 |
US2014170140(A1) |
申请公布日期 |
2014.06.19 |
| 申请号 |
US201214113061 |
申请日期 |
2012.04.23 |
| 申请人 |
Bennett Jeffrey L.;Owens Gregory P.;Verkman Alan S. |
发明人 |
Bennett Jeffrey L.;Owens Gregory P.;Verkman Alan S. |
| 分类号 |
C07K16/18;A61K39/395;A61K47/48;A61K45/06 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method of treating a subject with neuromyelitis optica (NMO) spectrum disease comprising administering to said subject an reagent comprising an anti-aquaporin-4 (AQP4) antibody or an antigen binding fragment thereof, wherein said reagent lacks effector functions of an intact antibody.
|
| 地址 |
Aurora CO US |
