COMPOSITIONS AND METHODS RELATED TO ANTIBODIES TO STAPHYLOCOCCAL PROTEIN A

摘要

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).

主权项

1. A method of treating or preventing a Staphylococcus infection comprising administering to a patient having a Staphylococcus infection or at risk of a Staphylococcus infection an effective amount of a purified SpA binding polypeptide that is capable of specifically binding at least two SpA IgG binding domains A, B, C, D and E of a Spa variant that lacks non-specific Ig-binding activity.