| 发明名称 |
BIOMARKER FOR CORONARY ARTERY DISEASE |
| 摘要 |
In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde-acetaldehyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction. |
| 申请公布号 |
US2014170068(A1) |
申请公布日期 |
2014.06.19 |
| 申请号 |
US201214004514 |
申请日期 |
2012.03.12 |
| 申请人 |
Thiele Geoffrey M.;Anderson Daniel R.;Duryee Michael J. |
发明人 |
Thiele Geoffrey M.;Anderson Daniel R.;Duryee Michael J. |
| 分类号 |
G01N33/53;A61K49/00 |
主分类号 |
G01N33/53 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1: A method of identifying a mammal having an elevated risk for an adverse cardiac event and/or determining the prognosis for said mammal, said method comprising:
determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde-acetaldehyde adduct (MAA adduct) in a biological sample from said mammal, where an elevated level of said antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions.
|
| 地址 |
Omaha NE US |
