METHODS AND COMPOSITIONS FOR LOCALIZED DELIVERY OF AGENTS TO VIRALLY INFECTED CELLS AND TISSUES

摘要

The invention provides compositions and methods for delivering an agent to virally infected tissues and/or cells of a subject by conjugating agent-loaded nanoparticles to virus-specific T cells, such as cytotoxic T lymphocytes. The agent may be a latency-reversing drug (LRD), an antiviral agent and/or an agent that enhances cytotoxic efficacy of T lymphocytes.

主权项

1. A method for delivering an agent to Human Immunodeficiency Virus (HIV)-infected cells, the method comprising
administering, to a subject having or suspected of having an HIV infection, a HIV-specific T cell bound to a nanoparticle that comprises an agent, wherein the agent is released from the nanoparticle in vivo.