| 摘要 |
PROBLEM TO BE SOLVED: To provide new chemotherapy agents containing umirolimus formulations, which are soluble and stable in aqueous solution, have prolonged circulation after administration, and have tumor targeting capability.SOLUTION: A pharmaceutical formulation comprises umirolimus encapsulated in a liposome or a polymer micelle, and a pharmaceutically acceptable excipient, carrier, or diluent. The liposome includes a polyethylene glycol (PEG) conjugated phospholipid (PEGylated phospholipid) and a phosphatidylcholine (PC). The PEG has a length of 10-3,000 monomeric units. A pharmaceutical formulation that includes umirolimus encapsulated in a polymer micelle contains, as a polymer, a tri-arm block co-polymer or a block co-polymer which comprises a hydrophilic polymer conjugated to two hydrophobic polymers. |
