SYSTEMS, COMPOSITIONS AND METHODS FOR DETECTING A BIOLOGICAL CONDITION

摘要

Determining a biological condition in a mammal by using a cartridge, having fluidic open channels, sealable after receiving a fluid specimen, passing any of the specimen through any of the channels, contacting any reagent stored in a chamber with the specimen in a reaction chamber inducing a reaction and forming a reaction product, a mechanical controller including first urging means applying a force externally onto the chamber to release the reagent, second urging means applying a removable force onto the channels thereby inducing fluidic movement in a first direction in the channels and upon removal of the force causing fluidic movement in an opposite direction, alignment means aligning a reading channel on the cartridge for a detection to take place, an optical reader detecting the reaction product in the reading channel, and a processor receiving data from the optical reader and processing the data to determine the biological condition.

主权项

1. A system for determining a biological condition, the system comprising:
a) a stationary cartridge comprising a plurality of fluidic open channels, the cartridge being adapted to be sealed after receiving a fluid specimen and to pass a predetermined quantity of said specimen through at least part of said plurality of fluidic open channels; and further to contact at least one reagent stored in a sealed on-board storage chamber with said predetermined quantity of said specimen in a reaction chamber to induce a reaction and form a reaction product; b) a mechanical controller comprising;
i. a first urging means adapted to apply a force externally onto said storage chamber thereby releasing said at least one reagent;ii. at least one second urging means adapted to apply a removable force onto plurality of fluidic open channels thereby inducing fluidic movement in a first direction in said plurality of fluidic open channels and upon removal of said force causing fluidic movement in an opposite direction to said first direction;iii. an alignment means adapted to align a reading channel on said cartridge for a detection to take place; c) an optical reader adapted to detect said reaction product in said reading channel of said sealed cartridge; and d) a processor adapted to receive data from said optical reader and to process said data to determine said biological condition. A system according to claim 1, wherein said plurality of fluidic open channels are of a cross-section of 0.1 to 2 mm2.