| 主权项 |
1. A computerized method for quantifying the perturbation of a biological system in response to an agent, comprising
receiving, at a first processor, a set of treatment data corresponding to a response of a biological system to an agent, wherein the biological system includes or comprises a plurality of biological entities, each biological entity interacting with at least one other of the biological entities; receiving, at a second processor, a set of control data corresponding to the biological system not exposed to the agent; providing, at a third processor, a computational causal network model that represents the biological system and includes or comprises:
nodes representing the biological entities,edges representing relationships between the biological entities, anddirection values, for the nodes, representing the expected direction of change between the control data and the treatment data;calculating, with a fourth processor, activity measures, for the nodes, representing a difference between the treatment data and the control data;calculating, with a fifth processor, weight values for the nodes, wherein at least one weight value is different from at least one other weight value; andgenerating, with a sixth processor, a score for the computational model representative of the perturbation of the biological system to the agent, wherein the score is based on the direction values, the weight values and the activity measures.
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