| 摘要 |
The present invention provides a compound of which active |form| is represented by a formula (A). and which can be injected into a joint cavity which is an affected part of disorders and can be accumulated in the joint cavity to exert the pharmacological effect thereof in a sustained manner, for the purpose of ameliorating cartilage disorders without developing any side effect. A compound according to the present invention, which is represented by a formula (I):;;(wherein all of symbols are as defined in the description), is a compound that can achieve the above-mentioned purpose. This compound does not exhibit any side effect on the cardiovascular system even when the compound is administered in an effective amount for exhibiting a cartilage regeneration activity, and is therefore extremely useful as a safe and effective preventive and/or therapeutic agent for cartilage disorders. Since a suspension produced using this compound can be injected without requiring the incision of the affected part, it can reduce the burden on patients, and is extremely useful as a medicinal agent. |
| 主权项 |
1. A compound represented by a formula (I): wherein R1 is C10-22 alkyl, C10-22 alkenyl and C10-22 alkynyl, wherein an arrow of each group represents a bond position,
X is C2-4 alkylene;R1-1 is C10-20 alkyl optionally substituted by one phenyl, C10-20 alkenyl optionally substituted by one phenyl, C10-20 alkynyl optionally substituted by one phenyl, phenyl substituted by C10-20 alkyl, phenyl substituted by C10-20 alkenyl or phenyl substituted by C10-20 alkynyl;R1-2 is C1-3 alkyl or phenyl;R1-3 is C10-20 alkyl, C10-20 alkenyl, C10-20 alkynyl, C10-20 alkoxy, C10-20 alkenyloxy or C10-20 alkynyloxy;R2 is a hydrogen atom, hydroxy, oxo or a halogen atom;R3 is a hydrogen atom or hydroxy; represents a single bond or double bond;
represents binding to the opposite side of the sheet (namely α-configuration),
represents binding to the front side of the sheet (namely β-configuration),
represents that it is α-configuration, β-configuration or a mixture thereof at arbitrary ratio, a solvate thereof or a cyclodextrin clathrate thereof.
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