Factor VIII B cell epitope variants having reduced immunogenicity
摘要
Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII.
申请公布号
EP2742949(A1)
申请公布日期
2014.06.18
申请号
EP20130191686
申请日期
2010.11.15
申请人
PUGET SOUND BLOOD CENTER;JAMES, EDDIE ARTHUR
发明人
PRATT, KATHLEEN;ETTINGER, RUTH;JAMES, EDDIE ARTHUR
