Highly productive simulated moving bed chromatographic separation

摘要

The invention is directed to a simulated moving bed chromatographic separation process, and to a simulated moving bed chromatography apparatus for carrying out said process. The simulated moving bed chromatographic separation process of the invention comprises the steps of applying a feed mixture and a mobile phase in which said feed mixture is soluble to a simulated moving bed comprising a particulate stationary phase, and separating said feed mixture into an extract and a raffinate,
wherein said simulated moving bed comprises multiple radial flow columns connected in series into a loop, and
wherein the particulate stationary phase of said simulated moving bed has a median particle diameter of 100 µm or less.