Methods for treating obstructive sleep apnea

摘要

The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.

主权项

1. A method for treating obstructive sleep apnea (OSA) in a subject in need thereof, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep, wherein the effective amount of the pharmaceutical composition is selected to provide a target serum concentration of pyridostigmine in the subject in the range of 3-30 ng/ml for at least one hour during sleep.