| 发明名称 |
Crystalline form of a biphenyl compound |
| 摘要 |
The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder. |
| 申请公布号 |
US8754223(B2) |
申请公布日期 |
2014.06.17 |
| 申请号 |
US201313910708 |
申请日期 |
2013.06.05 |
| 申请人 |
Theravance, Inc. |
发明人 |
Chao Robert S.;Rapta Miroslav;Colson Pierre-Jean |
| 分类号 |
C07D215/38 |
主分类号 |
C07D215/38 |
| 代理机构 |
|
代理人 |
Hagenah Jeffrey A. |
| 主权项 |
1. A process for preparing a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester; the process comprising contacting biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester with 1,2-ethanedisulfonic acid or a hydrate thereof.
|
| 地址 |
South San Francisco CA US |
