Process for the manufacture of 4-fluoro-2-methyl-1H-indol-5-ol

摘要

The present invention relates to a chemical process for the manufacture of a compound of Formula II;

主权项

1. A process for the manufacture of a compound of Formula IIthe process comprising the steps of:
(a) in the presence of a solvent, reacting a compound of Formula III: wherein R1 and R2 are independently selected from the group consisting of chlorine, bromine, fluorine, iodine, triflyl and tosyl; with an ester of Formula IV wherein R3 isC1-6alkyl or benzyl;to form a compound of Formula V: (b) in the presence of an arylalkyl ammonium salt or a tetraalkyl ammonium salt, reacting a compound of Formula V with hydroxide ion to form a compound of Formula VI (c) in the presence of an acid, decarboxylating a compound of Formula VI to form a compound of Formula VII; and (d) reducing the compound of Formula VII to form the compound of Formula II.