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1. A compound of formula Ior a stereoisomer thereof, or a pharmaceutically acceptable salt of the compound or stereoisomer, wherein
X isoptionally substituted with one or more substituents selected from the group consisting of (C1-C5)alkyl, —O(C1-C3)alkyl, CN, Cl, F, CF3 and OH;
D is C(R5)2; E is C(R5)2; W is C(R4); M is a bond or C(O); or M is selected from the optionally substituted group consisting of —(C1-C4)alkyl, —C(O)N(R2), —N(R2)C(O), —N(R2), -aryl, -heterocyclyl and -heteroaryl; or M is selected from the optionally substituted group consisting of —(C1-C4)alkyl-heterocyclyl, —(C1-C4)alkyl-C(O), —(C1-C4)alkyl-C(O)N(R2), —(C1-C4)alkyl-C(O)O, —(C1-C4)alkyl-N(R2)C(O)O, —(C1-C4))alkyl-N(R2)C(O) and —CH2—NH—C(O) wherein the alkyl portion of the moiety is connected to W; T is H or is selected from the optionally substituted group consisting of indanyl, indenyl and phenyl; A is a bond or CH2; G is NH, NH—CH2, or NH—C(O), wherein the N is attached to A; Q is H or is selected from the optionally substituted group consisting of (C1-C5)alkyl, (C3-C7)cycloalkyl, —O—(C3-C7)cycloalkyl and —(C1-C3)alkyl-O—(C1-C3)alkyl; R1 is selected from the optionally substituted group consisting of 5,6,7,8-tetrahydro-[1,6]naphthyridinyl, phenyl, piperidinyl and quinazolinyl; R2 is independently selected from the optionally substituted group consisting of H, (C1-C4)alkyl and (C3-C5)cycloalkyl; R3 is independently H, OH, CN, F, CF3, C(O)N(R2)2, N(R2)2, or oxo; or R3 is independently selected from the optionally substituted group consisting of (C1-C3)alkyl, (C3-C7)cycloalkyl, (C1-C3)alkyl-O—(C1-C3)alkyl, —(C1-C3)alkyl-C(O)—O—(C1-C3)alkyl, aryl, -D-aryl, heteroaryl, heterocyclyl, —(C1-C3)alkyl-aryl, —N(R2)aryl, —O-aryl, —C(O)—O—(C1-C3)alkyl, —NH-phenyl and phenyl; R4 is H, OH, CN or F or R4 is selected from the optionally substituted group consisting of —O—(C1-C3)alkyl, —O—(C3-C7)cycloalkyl, aryl and heteroaryl; R5 is H or CH3; m and n are independently 0, 1, or 2; p is 1 or 2; x is 1 or 2; and y is 0, 1 or 2.
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