| 发明名称 | Pharmaceutical composition including a DHA ester to be administered parenterally | ||
| 摘要 | The present invention relates to a pharmaceutical composition to be parenterally administered, including submicronic ester particles of docosahexaenoic acid, dispersed in an aqueous phase using a mixture of at least two surfactants selected from among a) at least one polyoxyethylene fatty acid ester and b) at least one phospholipid derivative. The present invention also relates to the method for preparing said pharmaceutical composition. | ||
| 申请公布号 | US8753652(B2) | 申请公布日期 | 2014.06.17 |
| 申请号 | US201013389970 | 申请日期 | 2010.08.11 |
| 申请人 | Pierre Fabre Medicament | 发明人 | Leverd Elie;Van Hoogevest Peter;Kung Elsa;Leigh Mathew |
| 分类号 | A61K9/00;A61K47/14 | 主分类号 | A61K9/00 |
| 代理机构 | Birch, Stewart, Kolasch & Birch, LLP | 代理人 | Birch, Stewart, Kolasch & Birch, LLP |
| 主权项 | 1. A pharmaceutical composition to be administered parenterally, including submicronic ester particles of docosahexaenoic acid having a mean size <100 nm with a polydispersity <0.5, said particles being dispersed in an aqueous phase using a mixture of at least two surfactants selected from a) at least one polyoxyethylene fatty acid ester and b) at least one phospholipid, wherein the ester of docosahexaenoic acid is the panthenol ester of DHA having the following formula A:or any of the pharmaceutical acceptable salts, enantiomers, diastereoisomers thereof, or mixture thereof including racemic mixtures, or the ester of docosahexaenoic acid is the nicotinic ester, and wherein said composition is a dispersion of mixed micelles or vesicles or micellar and vesicular structure hybrids. | ||
| 地址 | Boulogne-Billancourt FR | ||