| 发明名称 | Compositions and methods for modulating the activity of complement regulatory proteins on target cells | ||
| 摘要 | This invention relates to agents capable of reducing the activity, amount or density of complement regulatory proteins (CRPs) on target cells. The invention also provides methods of identification of such agents, methods of making, and uses thereof. | ||
| 申请公布号 | US8753639(B2) | 申请公布日期 | 2014.06.17 |
| 申请号 | US201012751943 | 申请日期 | 2010.03.31 |
| 申请人 | University of Washington through its Center for Commercialization;Compliment Corporation | 发明人 | Lieber André;Wang Hongjie;Berenson Ronald Jay;Carter Darrick |
| 分类号 | C07K14/075 | 主分类号 | C07K14/075 |
| 代理机构 | Christensen O'Connor Johnson Kindness PLLC | 代理人 | Christensen O'Connor Johnson Kindness PLLC |
| 主权项 | 1. A modified polypeptide capable of reducing the activity, amount, or density of a complement regulatory protein (CRP) on a target cell surface, wherein the polypeptide comprises at least two loop domains with CRP binding affinity and has at least 90% sequence identity to the Ad35 fiber knob sequence of SEQ ID NO:3, wherein the first loop comprises amino acids 81-89 of SEQ ID NO:3 and the second loop comprises amino acids 120-126 of SEQ ID NO:3, wherein the polypeptide comprises at least one of a substitution of a glycine (Gly) for the aspartic acid (Asp) at position 85 of SEQ ID NO:3, a substitution of any amino acid for the threonine (Thr) at position 123 of SEQ ID NO:3, or both. | ||
| 地址 | Seattle WA US | ||