Development of phopholipid-capped gold nanoparticles (PLGNPs) as surface enhanced Raman scattering probes

摘要

The molecule is prepared by capping phospholipid on a single gold nanoparticle (GNP). Since the thiol-related molecule bounded on GNP shows the characteristic of surface-enhanced Raman scattering (SERS), the phospholipid-capped gold nanoparticle (PLGNP) can be formed as a nanoprobe applied on the detection device integrating optics and chemistry and used in the fields of biomedicine, medical diagnosis and environment for detecting, such as solutions containing salts or proteins.

主权项

1. A method for preparing a signaling molecule comprising a metal nanoparticle, the method comprising steps of:
(a) treating a surface of the metal nanoparticle with an acidic solution; (b) resolving the metal nanoparticle in a dimethylformamide (DMF) to obtain a first intermediate; (c) adding a phospholipid to the first intermediate; (d) adding a thiol molecule to the first intermediate to perform a heating process to obtain a second intermediate; and (e) separating the second intermediate to obtain the signaling molecule comprising the metal nanoparticle.