BIODEGRADABLE MICROBEADS WITH AN IMPROVED ABILITY TO ABSORB ANTITUMOR AGENT, COMPRISING ANIONIC POLYMER AND METHODS FOR PREPARING THEREOF

摘要

The present invention relates to a biodegradable microbead having improved adsorptive power to anticancer drugs, a method for preparing same, and a method for treating cancer using same. According to the present invention, a rigid bead having excellent adsorptive power to anticancer drugs can be prepared through cross-linking and an amide bond between an albumin and an anionic polymer. In addition, the microbead of the present invention is prepared by a biocompatible and biodegradable polymer so as to be safe when applied to the human body. Further, the microbead can effectively inhibit the growth of a tumor by effectively blocking a blood vessel which supplies nutrients to a liver tumor, while continuously releasing anticancer drugs which are adsorbed into the surface of the bead. Thus, the present invention can be usefully applied to a chemoembolization of liver cancer.