Fully synthetic implantable multi-phased scaffold

摘要

An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.

主权项

1. A fully synthetic implantable multi-phased scaffold comprising, in a single continuous construct, at least three phases wherein
a) exactly two of the at least three phases are end phases adjacent to exactly one other phase of the at least three phases, b) every phase, amongst the at least three phases, which is not an end phase is adjacent to exactly two other phases of the at least three phases, c) each of the two end phases comprises a material having a higher ceramic concentration than each phase, amongst the at least three phases, that is not an end phase; and d) at least one of the at least three phases comprises a polymer-ceramic composite in which the ceramic is dispersed in the polymer, so as to mimic the natural anatomy of a tendon or a ligament.