4-pyridinone compounds and their use for cancer

摘要

Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed.;

主权项

1. A compound having the structure:or a salt thereof, wherein:
X is NO2 or NH2; and PAm is —NH—Rb, —NHC(O)ORa, —NHC(═O)Ra, —NH(CH2Rc), —NHSi(Rd)3, —NH(PO(ORd)2, —NHSO2Re, —N(Rb)2, —N(C(O)ORa)2, —N(C(O)Ra)2, —N(CH2Rc)2, —N(Si(Rd)3), —N═C(Ra)2, or each Ra is independently H, alkyl, haloalkyl, benzyl, or aryl; each Rb is independently alkyl, haloalkyl, benzyl, methoxybenzyl, or aryl; each Rc is independently allyl or alkoxy; each Rd is independently alkyl; Re is alkyl, alkyl substituted with —Si(alkyl)3, phenyl, or nitrophenyl; and each Rf is independently alkyl or benzyl.