Multimodal imaging method using nano-emulsion comprising optical nano-particles and perfluorocarbons

摘要

The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varying the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted.

主权项

1. A multimodal imaging method in vivo using a nano-emulsion comprising quantum dot nano-particles reformed with a perfluorocarbon for surface reforming, and 19F-containing perfluorocarbons, the method comprising:
injecting the nano-emulsion in vivo to simultaneously perform multicolor ray emission of the quantum dot nano-particles and control of resonance frequencies in accordance with the kinds of 19F-containing perfluorocarbons (a first step); measuring the combined wavelength of the emitted rays and the controlled resonance frequency of the 19F-containing perfluorocarbons (a second step); wherein the quantum dot nano-particles reformed with a perfluorocarbon for surface reforming are dispersed in the 19F-containing perfluorocarbons; and the perfluorocarbon for surface reforming is not a 19F-containing perfluorocarbon.