Compositions and methods for visualizing and eliminating cancer stem cells

摘要

The present invention relates generally to the field of cancer diagnosis and treatment, and more particularly to compositions and methods that may be useful for eliminating cancer cells with stem-like characteristics. The disclosed compositions and methods may also be useful for managing breast cancer, ovarian cancer, cervical cancer or endometrial (uterine) cancer with metastases; and visualizing the cancer cells in patient's body. The compositions of the instant invention include human prolactin receptor antagonist G129R.

主权项

1. A method for inhibiting growth of cancer cells in a patient, comprising administering to the patient an effective amount of a human prolactin receptor antagonist comprising the sequence of SEQ ID NO: 4 in which a glycine residue at position 129 is substituted with another amino acid;
wherein the cancer cells do not express estrogen receptor, progesterone receptor and HER2/neu; and further wherein the cancer cells are selected from the group consisting of ovarian cancer cells, uterine (endometrial) cancer cells, cervical cancer cells and breast carcinoma cells.