发明名称 |
Sammensætninger og fremgangsmåder til hæmning af ekspressionen af proapoptotiske gener |
摘要 |
The invention relates to one or more inhibitors, in particular siRNA compounds, which down-regulate the expression of a pro-apoptotic gene selected from the group consisting of TP53; HTRA2; KEAP1; SHC1-SHC, ZNHIT1, LGALS3 and HI95. The invention also relates to a pharmaceutical composition comprising the compound, and a pharmaceutically acceptable carrier. The present invention further provides methods of treating a subject afflicted with a disease or a condition associated with those genes, comprising administering to the subject a pharmaceutical composition in a therapeutically effective dose so as to thereby treat the subject. |
申请公布号 |
DK2170403(T3) |
申请公布日期 |
2014.06.16 |
申请号 |
DK20080763631T |
申请日期 |
2008.06.26 |
申请人 |
QUARK PHARMACEUTICALS, INC. |
发明人 |
KALINSKI, HAGAR;METT, IGOR;FEINSTEIN, ELENA;ERLICH, SHAI, DR |
分类号 |
C12N15/113;A61K31/713 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|