SUBSTITUTED PYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS

摘要

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:;;wherein R1, R2, ring A, and G are defined herein.

主权项

1. A compound of Formula (I) wherein
R1 is selected from the group consisting of C1-4alkyl, C1-4alkoxy, di(C1-4alkyl)amino, chloro, trifluoromethoxy, trifluoromethyl, and cyano;ring A is phenyl or a heteroaryl selected from the group consisting of pyridinyl, thienyl, benzofuranyl, quinolinyl, and indolyl;R2 is selected from the group consisting of C1-4alkyl, C1-4alkoxy, C1-4alkylthio, cyano, fluoro, chloro, hydroxy, and di(C1-4alkyl)amino;G is G1, G2, G3, or G4; whereinQ is selected from the group consisting of O, S, SO2, N—R4, CH2, CH(R5), CF2, C(CH3)2, C(O), and a spirofused W is selected from the group consisting of O, S, CH(OH), C(O), S(O), SO2, and N—R4;R3 and R4 are each independently selected from the group consisting of 2,2,2-trifluoroethyl, di(C1-4alkyl)aminocarbonyl, N-methoxy-N-methylaminocarbonyl, phenylcarbonyl, C1-4alkylcarbonyl, trifluoromethylcarbonyl, C1-4alkoxycarbonyl, C1-4alkylsulfonyl, C3-7cycloalkylsulfonyl, trifluoromethylsulfonyl, and 3,5-dimethylisoxazol-4-ylsulfonyl;R5 is trifluoromethylcarbonylamino, amino, or C1-4alkoxycarbonylamino; and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.