FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION

摘要

Novel functionalized benzamide derivatives are provided. Also provided are pharmaceutical compositions comprising therapeutically effective amounts of functionalized benzamide derivatives useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection, in combination with at least one pharmaceutically acceptable excipient. Functionalized benzamide derivatives of the invention include N-aryl-substituted 1-naphthamide and 2-naphthamide derivatives.