主权项 |
1. A method for closing a skin ulcer, comprising applying a cyanoacrylate adhesive composition to the skin ulcer and allowing the composition to cure on the ulcer, thereby closing the ulcer, wherein the composition comprises a mixture of about 78% to about 82% by weight of monomeric 2-octyl cyanoacrylate, about 22% to about 18% by weight of monomeric n-butyl cyanoacrylate, about 2000 ppm to about 14,000 ppm of butylated hydroxyl anisole, and about 10 ppm to about 200 ppm of sulfur dioxide or about 5 ppm to about 50 ppm of an acid stabilizer selected from the group consisting of sulfuric acid, phosphoric acid, and perchloric acid, wherein the composition is sterilized by electron beam (E-beam) irradiation, wherein the viscosity of the sterilized composition increases by no more than about 300% over a period of at least two years of shelf storage, and wherein the composition does not contain any plasticizer.
|