METHOD AND SYSTEM FOR TUNING A CLOSED-LOOP CONTROLLER FOR AN ARTIFICIAL PANCREAS

摘要

Described and illustrated is a system for management of diabetes that includes an infusion pump, glucose sensor and controller with a method programmed into the controller. The infusion pump is configured to deliver insulin to a subject. The glucose sensor is configured to sense glucose levels in the subject and provide output signals representative of the glucose levels in the subject. The controller is programmed receives signals from at least one of the glucose sensor and the pump and configured to issue signals to the pump to deliver an amount of insulin determined by a feedback controller that utilizes a model predictive control of the subject based on desired glucose levels, insulin amount delivered and measured glucose levels of the subject. The controller is also configured to deliver insulin using a tuning factor based on either one of an omission index module or a calibration index module.

主权项

1. A method to control an infusion pump with a controller to control the pump and receive data from at least one glucose sensor, the method comprising:
measuring glucose level in the subject from the glucose sensor to provide at least one glucose measurement in each time interval in a series of discrete time interval index (“k”); obtaining a glucose calibration measurement during at least one time interval in the series of time interval index to provide for a calibration index; ascertaining whether one or more glucose measurements were not provided during a time interval of the series of time interval index to provide for an omission index; determining a tuning factor based on both the calibration index and omission index; calculating insulin amount for delivery by the controller based on a model predictive controller that utilizes (a) the plurality of glucose measurements to predict a trend of the glucose level from estimates of a metabolic state of the subject and (b) the tuning factor so as to provide a calculated insulin amount to be delivered to the subject for each interval of the interval index; delivering insulin amount determined from the calculating step.