| 发明名称 |
Bystander Immune Suppression as a Predictor for Response to a Vaccine |
| 摘要 |
The present invention relates to antigen-specific immune regulatory response. Methods for detecting an antigen-specific immune regulatory response, methods for selecting candidate vaccine recipients, and methods for improved vaccination strategies are presented. |
| 申请公布号 |
US2014161818(A1) |
申请公布日期 |
2014.06.12 |
| 申请号 |
US201314098679 |
申请日期 |
2013.12.06 |
| 申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
McNeel Douglas G.;Burlingham William J. |
| 分类号 |
A61K39/395;A61K39/00 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for administering a prostate cancer vaccine to an individual having an antigen-specific suppressive immune response to the prostate cancer vaccine, the method comprising the step of administering to the individual the prostate cancer vaccine and an agent that suppresses an immunosuppressive function of at least one immune regulatory cell-associated molecule,
wherein the antigen-specific suppressive immune response is characterized by the presence in the individual of CD8+/IL-35+/CTLA-4+ T-lymphocytes.
|
| 地址 |
Madison WI US |
