发明名称 ANTI-PCSK9 AND METHODS FOR TREATING LIPID AND CHOLESTEROL DISORDERS
摘要 The present invention provides compositions and methods for treating disorders of cholesterol and lipid metabolism by administration of an anti-PCSK9 antibody or a peptide inhibitor of PCSK9.
申请公布号 US2014161798(A1) 申请公布日期 2014.06.12
申请号 US201314094560 申请日期 2013.12.02
申请人 Merck Sharp & Dohme Corp. 发明人 Hedrick Joseph A.;Monsma Frederick James;Churakova Tatyana;Hollenbaugh Diane
分类号 C07K16/40;A61K45/06;A61K31/397;A61K39/395 主分类号 C07K16/40
代理机构 代理人
主权项 1. An isolated antibody or antigen-binding fragment thereof comprising one or more members selected from the group consisting of: (i) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 11B5 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 10; (ii) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 75B9 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 18; (iii) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 77D10 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 26; (iv) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 29C10 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 34; (v) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 22D11 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 42; (vi) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 1F11/1G11 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 50; (vii) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 11B5 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 14; (viii) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 75B9 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 22; (ix) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 77D10 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 30; (x) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 29C10 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 38; (xi) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 22D11 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 46; and (xii) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 1F11/1G11 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 54.
地址 Rahway NJ US