主权项 |
1. An isolated antibody or antigen-binding fragment thereof comprising one or more members selected from the group consisting of:
(i) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 11B5 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 10; (ii) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 75B9 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 18; (iii) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 77D10 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 26; (iv) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 29C10 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 34; (v) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 22D11 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 42; (vi) CDR-H1, CDR-H2 and CDR-H3 of the variable region the 1F11/1G11 heavy chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 50; (vii) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 11B5 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 14; (viii) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 75B9 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 22; (ix) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 77D10 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 30; (x) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 29C10 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 38; (xi) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 22D11 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 46; and (xii) CDR-L1, CDR-L2 and CDR-L3 of the variable region the 1F11/1G11 light chain immunoglobulin which comprises the amino acid sequence of SEQ ID NO: 54.
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