AUGMENTATION OF CELL THERAPY EFFICACY INCLUDING TREATMENT WITH ALPHA 1-3 FUCOSLYTRANSFERASE

摘要

Disclosed are methods, compositions of matter, and kits useful for augmentation of cells through modification of cellular membrane properties following ex vivo treatment.

主权项

1. A method of enhancing homing and engraftment of a T cell population, the method comprising the step of:
administering a population of modified T cells to a patient in need thereof, the population of cells being modified by contact with an α1,3-fucosyltransferase that modified at least one surface molecule on the T cells to enhance selectin mediated binding thereof.