RECOMBINANT INFLUENZA VIRUSES AND CONSTRUCTS AND USES THEREOF

摘要

Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.

主权项

1. A recombinant protein comprising a mutated influenza virus RNA-dependent RNA polymerase, wherein the mutated influenza virus RNA-dependent RNA polymerase comprises a mutated PA polymerase subunit.