METABOLOMIC PROFILING DEFINES ONCOGENES DRIVING PROSTATE TUMORS

摘要

The invention provides methods and products to identify metabolic status of Aktl and Myc in tumors, and to treat cancer. The method comprises performing an assay to measure a profile of metabolites in a prostate tumor sample obtained from a subject, wherein the metabolites are differentially produced in prostate tumors with high Aktl expression versus prostate tumors with high Myc expression; and comparing, with at least one processor, the profile of metabolites with an appropriate reference profile of the metabolites to assign an Aktl and Myc metabolic status to the sample based on results of the comparison.