发明名称 |
Siglec 15 antibodies in treating bone loss-related disease |
摘要 |
Novel antibodies and antigen binding fragments that specifically binds to Sιglec-15 are described herein In some embodiments, the antibodies or antigen binding fragments may block the biological activity of Sιglec-15 and are useful in composition for the treatment of bone loss, more particularly in bone diseases that have increased cell surface expression of Sιglec-15, such as conditions where there is an increase in the bone degradative activity of osteoclasts The invention also relates to cells expressing the antibodies or antigen binding fragments such as monoclonal, humanized or chimeric antibodies Additionally, methods of detecting and treating bone loss, bone-related diseases or cancer using the antibodies and fragments are also disclosed. |
申请公布号 |
AU2010305281(B2) |
申请公布日期 |
2014.06.12 |
申请号 |
AU20100305281 |
申请日期 |
2010.10.06 |
申请人 |
ALETHIA BIOTHERAPEUTICS INC. |
发明人 |
TREMBLAY, GILLES BERNARD;FILION, MARIO;STUIBLE, MATTHEW |
分类号 |
C07K16/28;A61K31/7088;A61K31/713;A61K39/395;A61K49/00;A61P19/08;A61P35/00;C12N5/077;G01N33/53;G01N33/574 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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