| 主权项 |
1. A compound having a structure represented by formula (V) or any tautomeric or stereoisomeric form thereof, wherein R7 is selected from —S(O)m—R17, with m=0, 1 or 2, and —N(R1)—V—R2; R18 is taken from the list of —W—R4, —COOH, —COOR17, and —Br; and R17 is independently selected from —C1-6-alkyl, —CH2-aryl, or -aryl; with R1 is selected from hydrogen, —C1-6alkyl, —C2-6-alkenyl, —C2-6-alkynyl, —C3-6-cycloalkyl and —C3-6-cycloalkenyl; V is selected from a bond, —O—, —N(R11)—, —C(═X)—, —S(O)n—, —C(═X)—O—, —C(═X)—N(R11)—, —C(═X)—S—, —C(═X)—N(R11)—N(R11)—, —N(R11)—C(═X)—, —N(R11)—C(═X)—N(R11)—, and —N(R11)—S(O)n—, with n=1 or 2; R2 is selected from hydrogen, -alkyl, -alkenyl, -alkynyl, -cycloalkyl, -cycloalkenyl, -heterocycloalkyl, -heterocycloalkenyl, -aryl and -heteroaryl; or, R1 and R2, together with V and the nitrogen atom they are attached to, form a heterocycle; R3 is selected from hydrogen, —C1-6alkyl, —C2-6-alkenyl, —C2-6-alkynyl, —C3-6-cycloalkyl, —C3-6-cycloalkenyl and halogen; W is a bond, or —C(═O)—; R4 is selected from hydrogen, phenyl ans substituted phenyl; R5 is selected from -alkyl, -alkenyl, -alkynyl, -cycloalkyl, -cycloalkenyl, —(C-linked-heterocycloalkyl), —(C-linked-heterocycloalkenyl), -aryl, and -heteroaryl; X is independently selected from ═O, ═S, ═NR12, ═N—OR13, ═N—N(R11)2, ═N—N(R11)(R12), and ═N—N(R12)2; R10 is independently selected from —C1-6alkyl, —C2-6-alkenyl, —C2-6-alkynyl, —C3-6-cycloalkyl and —C3-6-cycloalkenyl; R11 is independently selected from hydrogen and R10; R12 is independently selected from -alkyl, -alkenyl, -alkynyl, -cycloalkyl, -cycloalkenyl, -heterocycloalkyl, -heterocycloalkenyl, -aryl and -heteroaryl; R13 is independently selected from hydrogen and R12; wherein R2, R4, R5, R10, and R12 may optionally be substituted; provided that if R7 is —N(R1)—V—R2, then R18 is not —W—R4.
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