TRANSDERMAL FORMULATION CONTAINING COX INHIBITORS

摘要

Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a COX-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.

主权项

1. A pharmaceutical composition, comprising:
a selective COX-2 inhibitor, forming a plurality of solid particles; a penetration enhancing compound; at least one solubilizer; a wetting agent; a gel forming agent; a solvent comprising water; and at least one volatile siloxane agent coating the selective COX-2 inhibitor, wherein the solid particles are dispersed in the composition, and wherein the composition comprises a suspension gel.