Compositions and Imaging Methods Comprising Detectably Labeled Phosphatidylethanolamine-Binding Peptides

摘要

Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.

主权项

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a substantially cell impermeant phosphatidylethanolamine (PE)-binding peptide that comprises a duramycin or cinnamycin peptide operatively attached to a cell impermeant group; wherein operative attachment of said duramycin or cinnamycin peptide to said cell impermeant group reduces the non-specific toxicity of the natural form of said duramycin or cinnamycin peptide by substantially inhibiting the ability of said duramycin or cinnamycin peptide to penetrate normal cells.