The present invention provides a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP- cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding TH is linked to the nucleotide sequence encoding CHI such that they encode a fusion protein TH-CH1. The invention also provides a viral vector comprising such a nucleotide sequence and its use in the treatment and/or prevention of Parkinson's disease.
申请公布号
AU2012328166(A1)
申请公布日期
2014.06.12
申请号
AU20120328166
申请日期
2012.10.26
申请人
OXFORD BIOMEDICA (UK) LIMITED
发明人
MITROPHANOUS, KYRIACOS;RALPH, SCOTT;STEWART, HANNAH;KINGSMAN, ALAN