| 发明名称 |
TREATMENT WITH HUMAN GROWTH HORMONE ANALOGUES |
| 摘要 |
The present invention concerns an improved therapeutic regimen for GHD therapy. In particular, the invention concerns methods for bolus dose administration of a human growth hormone-XTEN (hGH-XTEN) fusion protein. |
| 申请公布号 |
US2014162949(A1) |
申请公布日期 |
2014.06.12 |
| 申请号 |
US201313829369 |
申请日期 |
2013.03.14 |
| 申请人 |
Harazin Michael;Amunix Operating Inc. |
发明人 |
Cleland Jeffrey L.;Bright George M.;Humphriss Eric;Schellenberger Volker;Silverman Joshua;Stemmer Willem P.;Wang Chia-Wei;Geething Nathan;Spink Benjamin |
| 分类号 |
C07K14/61;G01N33/566;C07K14/00 |
主分类号 |
C07K14/61 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating human growth hormone deficiency (GHD), comprising administering to a human patient with GHD a human growth hormone-XTEN (hGH-XTEN) fusion protein comprising an amino acid sequence having at least about 90% sequence identity to SEQ ID NO:1, as a therapeutically effective bodyweight adjusted bolus dose between about 0.05 mg/kg and about 3.0 mg/kg.
|
| 地址 |
San Diego CA US |
