Kruppel-like Factor 10 (KLF10) as a Biomarker of Endothelial Progenitor Cell Dysfunction

摘要

The use of Kruppel-like Factor (KLF10) as a diagnostic and prognostic tool for peripheral artery disease and other disease conditions associated with reduced angiogenesis or endothelial progenitor cell dysfunction such as diabetes and stent thrombosis.

主权项

1. A method of predicting risk of developing or diagnosing the presence of peripheral artery disease (PAD), stent thrombosis, ischemic coronary artery disease, ischemic cardiomyopathy, or transplantation arteriosclerosis in a subject, the method comprising:
determining a level of Krüppel-like Factor (KLF10) expression in a sample comprising peripheral blood cells from the subject; and comparing the level of KLF10 in the sample to a reference level of KLF10; wherein the presence of a level of KLF10 in the sample below the reference level indicates that the subject has or is at risk of developing PAD, stent thrombosis, ischemic coronary artery disease, ischemic cardiomyopathy, or transplantation arteriosclerosis.